Angiogenesis and Invasiveness in Prostate Cancer Detected with High Spectral and Spatial Resolution MRI
Abstract
This grant is currently in a no-cost extension and we have made substantial progress on each of the specific aims of the proposal. In the last year, three papers were published in peer-reviewed journals describing work supported by this grant. In addition, there were four presentations at international meetings. Several grants have been funded based on preliminary results that were obtained with DAMD funding. Therefore, we will be able to continue this work, even though this is our last year of DAMD funding. Substantial improvement in high spectral and spatial resolution data acquisition and processing were made. In addition, experimental data demonstrated that HiSS MRI shows novel anatomic features that are not detected by conventional MRI, both in human volunteers and in rodent models of prostate cancer. Statistical analysis demonstrates that lesion morphology is significantly different in HiSS images compared to conventional images, and in images of off-peak' Fourier Component images, compared to water peak height images. During the final funding period, we plan to scan more volunteers and man with prostate cancer. In addition, we plan to extend our work on Fourier Component Imaging in order to demonstrate that this new approach to imaging provides unique contrast.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2005
- Accession Number
- ADA438426
Entities
People
- Gregory S. Karczmar
Organizations
- University of Chicago