A System for Discovering Bioengineering Threats by Knowledge Base Driven Mining of Toxin Data

Abstract

The overall goal of this project is to establish a Toxin Knowledge Base (TKB) a bioinformatics resource primarily focused on molecular information about toxins and other virulence factors that are the natural products of biological and potential biological warfare (RW and PBW) agents. The resource will be mined to assimilate synthesize, analyze and disseminate genomic and structural information on BW and PBW genes and their products. The TKB will be designed and developed to serve as a powerful analysis and decision system tool for the intelligence community. In this first annual report we describe in detail the TKB system that we have developed that can be used to identify homologs of toxins. The TKB contains molecular, biological and structural information of about 1000 toxins and is still being expanded. TKB will also use innovative computer methods to parse the literature available in public resources (web sites) to identify% new and emerging toxins to be included in the database.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2005
Accession Number
ADA438562

Entities

People

  • Hasan Davulcu
  • I. V. Ramakrishnan
  • M. Kifer
  • Subramanyam Swaminathan

Organizations

  • Brookhaven National Laboratory

Tags

DTIC Thesaurus Topics

  • Acquisition
  • Biological Products
  • Biological Toxins
  • Biological Warfare
  • Biomedical Information Systems
  • Computational Biology
  • Computational Science
  • Computer Science
  • Computers
  • Data Acquisition
  • Databases
  • Information Science
  • Internet
  • Machine Learning
  • Three Dimensional
  • User Interface
  • Websites

Readers

  • Critical Infrastructure Protection in CBRN and WMD Threats.
  • Molecular Genetics
  • Polymer Science and Engineering.

Technology Areas

  • Biotechnology