Molecular Epidemiology of Prostate Cancer
Abstract
This is the Final Report for this project. It provides new updated information since the last report, which was submitted in June 2004, and provides an overall summary of progress, and remaining steps required to meet the study objectives. Although those objectives were not completed during the funding period, they will be completed using other funding sources. The objective of this case-control study is to determine whether oxidative damage is a risk factor for prostate cancer, and whether this mechanism mediates the association between dietary fat and prostate cancer risk. Specifically, cases and controls will be compared with respect to malondialdehyde (MDA) in serum as a measure of oxidative stress, and deoxyguanosine malondialdehyde (dG-MDA) in peripheral lymphocytes and prostate tumor samples as a measure of oxidative DNA damage. In addition to these measures, dietary intake of fats and specific fatty acids, and of antioxidants will be considered as potential effect modifiers or confounding factors, as will serum antioxidant levels. Enrollment of cases and controls, collection of questionnaire data, and collection of serum, plasma and lymphocytes has been completed.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2005
- Accession Number
- ADA439125
Entities
People
- Bruce J Trock
Organizations
- Johns Hopkins University