In Vitro Partial-Body Dose Assessment Using a Radiation Responsive Protein Biomarker
Abstract
Exposure of humans, accidental or occupational, to ionizing radiation poses significant health hazards. The objective of this study was to evaluate the response of a radiation responsive protein biomarker after a simulated partial-body ionizing radiation exposure. The radiation responsive protein biomarker studied was Growth Arrest DNA-Damage (GADD-45)alpha. For a 6-Gray gamma dose, the GADD-45 alpha signal increased linearly as the percentage irradiated increased. These results support the use of molecular biomarkers to contribute in a multi-parameter diagnostic strategy for radiation exposure assessment. Keywords: partial-body simulation, GADD-45 alpha, microsphere-immunoassay, ionizing radiation, biological dosimetry, LuminexTM
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2005
- Accession Number
- ADA439126
Entities
People
- Jason M. Leidel
Organizations
- Uniformed Services University of the Health Sciences