Suppression of Breast Cancer Progression by Tissue Factor
Abstract
Tissue Factor (TF) is the cell surface receptor that activates coagulation by binding the serine protease coagulation factor VIIa (VIIa). The activation of the coagulation cascade leads to thrombin generation, fibrin formation and platelet activation which together may aide tumor growth and metastasis. While the role of TF in metastasis through thrombin pathways is well established, evidence is increasing that TF may drive tumor development dependent on cell signaling pathways that involve either the cytoplasmic domain or proteolytic activation of protease activated receptors by TF associated proteases. A newly developed breast cancer model with a tetracycline regulated TF expression-cassette shows that TF enhances breast cancer tumor growth. This model will be useful to study mechanisms by which TF enhances breast cancer progression. Tranagenic models are ongoing to test whether the TF cytoplasmic domains overall supports of suppresses breast cancer progression.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2005
- Accession Number
- ADA439141
Entities
People
- Wolfram Ruf
Organizations
- Scripps Research