Targeted Gene Therapy for Breast Cancer
Abstract
During the last three years of support of the career development award, we sought to develop and evaluate recombinant adeno-associated virus vectors encoding anti- angiogenic factors. We have completed the work with significant outcome, and also initiated new studies that will allow us to test novel possibilities for breast cancer treatment. The outcome of the present studies strongly indicated that sustained expression of anti-angiogenic factors not only provide significant growth inhibition of localized cancer in mouse model but also exerted tumor-free survival in combination with chemotherapy. We have also identified that the effect of anti-angiogenic therapy with rAAV in combination with chemotherapy, was independent of surviving pathway. Histopathological analysis of major visceral organs and liver enzyme analysis also revealed no toxicity because of combination therapy.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2005
- Accession Number
- ADA439170
Entities
People
- Selvarangan Ponnazhagan
Organizations
- University of Alabama