Hypo-Fractionated Conformal Radiation Therapy to the Tumor Bed After Segmental Mastectomy
Abstract
This IDEA grant proposal tested the feasibility of a regimen of conformal hypo-fractionated radiotherapy (5 fractions in 2 weeks) directed to the original tumor bed with margins in a selected subset of post-menopausal women with breast cancer with a very low risk for local recurrence elsewhere in the breast. The relevance of this approach consists of the fact that if proven equivalent in efficacy it would be more patient-friendly (30 fractions over 6 weeks) convenient and economical. This final report demonstrated feasibility in all 63 patients accrued to the trial, with minimal acute side effects. Among the 53 patients with at least 6 months follow-up late effects were limited to the rare occurrence of modest fibrosis and teleangectasia. With a median follow up of 24 months, in none of the patients breast cancer has recurred. Prone partial breast radiotherapy, delivered by an external beam simple technique over 5 fractions was feasible and very well tolerated. These results need to be confirmed in a larger cohort of patients, ideally in a multi-institutional setting.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2005
- Accession Number
- ADA439208
Entities
People
- Silvia C. Formenti
Organizations
- New York University