Magnetic Resonance Imaging of Polymeric Drug Delivery Systems in Breast Cancer Solid Tumors

Abstract

The overall purpose of this research is to develop a polymeric drug delivery system containing magnetic resonance contrast agents for the treatment of breast cancer. This drug-imaging agent delivery system will allow the follow up of the fate of the drug delivery system and its relation to reduced tumor mass, improved efficacy and reduced toxicity in individual patients. In year one progress was made in the following areas: 1) Synthesis of polymer-linked contrast agent conjugates; 2) Physicochemical characterization of polymer-linked contrast agent conjugates; 3) Relaxivity and stability measurements of polymer-linked contrast agent conjugates. In addition I completed my coursework (overall UPA=3.6), presented the results in the 2005 Era of Hope Meeting, and participated in other scientific meetings related to my field.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2005
Accession Number
ADA439254

Entities

People

  • Bahar Zarabi
  • Hamid Ghandehari

Organizations

  • University of Maryland, Baltimore

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Breast Cancer
  • Contrast
  • Copolymers
  • Drug Therapy
  • Electron Paramagnetic Resonance
  • Free Radicals
  • Gadolinium
  • Magnetic Resonance
  • Magnetic Resonance Imaging
  • Measurement
  • Molecular Weight
  • Neoplasms
  • Paramagnetic Resonance
  • Polymers
  • Resonance

Fields of Study

  • Medicine

Readers

  • Medical Imaging.
  • Neurotoxicology
  • Research Science/Academic Research