Bioenergetic Approaches and Inflammation in MPTP Toxicity

Abstract

We wish to continue to examine a number of new neuroprotective agents in the MPTP model of PD, which act by inhibiting the mitochondrial permeability transition (MPT) We also wish to utilize metabolomic profiling to identify novel biomarkers for PD and to investigate whether these occur in animal models of PD. We will develop and characterize a new animal model of PD making a knockout of PINK1, which is a nuclear-encoded kinase localized to mitochondria, and which causes autosomal recessive PD. Lastly, we wish to study the effects of human dopaminergic stem cells in the 6-hydroxy-dopamine model of PD.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2005
Accession Number
ADA439263

Entities

People

  • M. F. Beal

Organizations

  • Cornell University

Tags

DTIC Thesaurus Topics

  • Arteries
  • Brain
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Genetics
  • Health Services
  • Laboratory Animals
  • Neurodegeneration
  • Neurons
  • Neurosciences
  • Parkinson'S Disease
  • Proteins
  • Stem Cells

Fields of Study

  • Biology
  • Chemistry

Readers

  • Molecular and Cellular Biology
  • Neurodegenerative Parkinson's Disease and Rickettsial Disease handbook, including the data level of dopamine, BC, neurons, and PD.

Technology Areas

  • Biotechnology