Derivation of Double-Targeted Adenovirus Vectors for Gene Therapy of Prostate Cancer

Abstract

The subject of these studies is the development of targeted vector for selective infection and killing prostate cancer cells. The resultant vector is to be administered to prostate cancer patients to find, infect and destroy tumor cells. Targeting of the vector to prostate tumors is to be accomplished via incorporation into its capsid of ligands, which selectively bind to prostate-specific membrane antigen (PSMA).

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2005
Accession Number
ADA439290

Entities

People

  • Victor Krasnykh

Organizations

  • The University of Texas MD Anderson Cancer Center

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Adenoviruses
  • Biomedical Research
  • Cell Line
  • Cells
  • Gene Delivery
  • Gene Therapy
  • Infection
  • Membranes
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Targeting
  • Therapy
  • Viral Structures
  • Viruses
  • Wound Infections

Fields of Study

  • Medicine

Readers

  • Molecular Genetics
  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech