Genetic Susceptibility to Prostate Cancer in the Netherlands

Abstract

Studies of the genetics of populations that were historically endogamous for reasons of geography, religion, or language have contributed substantially to our understanding about hereditary predisposition to cancer. One such population is found in the Netherlands where multiple, prevalent, population-specific founder mutations have been identified. Genetic susceptibility to prostate cancer is being investigated in the Netherlands Cohorts Study (NLCS) on Diet and Cancer, which has identified over 800 cases of prostate cancer among 58,279 male participants. From this study, we have identified 300 cases and 300 controls from men of comparable age to identify markers near prostate cancer susceptibility genes that are present at higher frequency in the group of men with prostate cancer. We optimized the methods for analysis of these markers and observed a candidate region of association on chromosome 1.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2004
Accession Number
ADA439851

Entities

People

  • Harry Ostrer

Organizations

  • New York University

Tags

DTIC Thesaurus Topics

  • Amplification
  • Chromosomes
  • Classification
  • Diseases And Disorders
  • Genes
  • Genetics
  • Genome
  • Genotypes
  • Geography
  • Language
  • Medical Personnel
  • Mutations
  • Neoplasms
  • New York
  • Prostate
  • Prostate Cancer
  • Standards

Fields of Study

  • Biology

Readers

  • European Security and Defence Policy (ESDP).
  • Molecular and genetic basis of cancer.
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.

Technology Areas

  • Biotechnology