Reconfigurable Microfluidic System Architecture Based on Two-Dimensional Electrowetting Arrays

Abstract

We present an architectural design and optimization methodology for performing biochemical reactions using two-dimensional electrowetting arrays. We define a set of basic microfluidic operations and leverage electronic design automation principles for system partitioning, resource allocation, and operation scheduling. Fluidic operations are carried out by properly configuring a set of grid points. While concurrency is desirable to minimize processing time, the size of the two-dimensional array limits the number of concurrent operations of any type. Furthermore, functional dependencies between the operations also limit concurrency. We use integer linear programming to minimize the processing time by automatically extracting parallelism from a biochemical assay. As a case study, we apply our optimization method to the polymerase chain reaction.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2005
Accession Number
ADA440415

Entities

People

  • Jie Ding
  • Krishnendu Chakrabarty
  • Richard B. Fair

Organizations

  • Duke University

Tags

Communities of Interest

  • Biomedical
  • Materials and Manufacturing Processes

DTIC Thesaurus Topics

  • Abstracts
  • Albumins
  • Arrays
  • Availability
  • Case Studies
  • Chain Reactions
  • Chemical Reactions
  • Computer Programming
  • Computers
  • Contrast
  • Engineering
  • Integer Programming
  • Linear Programming
  • Optimization
  • Polymerase Chain Reaction
  • Scheduling (Production)
  • Two Dimensional

Fields of Study

  • Computer science

Readers

  • Integrated Circuit Design and Technology.
  • Molecular and Cellular Biochemistry
  • Parallel and Distributed Computing.

Technology Areas

  • Microelectronics