Pharmacologic Modification of the Cellular Energy Changes Produced by Hemorrhagic Shock

Abstract

Resuscitation from hemorrhagic shock with fluid (Ringer's Lactate) and blood may not correct all of the metabolic abnormalities associated with shock. Patients who are apparently fully resuscitated may yet develop organ failure syndromes such as respiratory failure and renal failure. The objective of our research has been to evaluate the therapeutic efficacy of three pharmacological agents which have been suggested as adjuncts to standard resuscitation (glutamine, crocetin, and dehydroepiandrosterone (DHEA)) by studying their use in a rodent model. The emphasis throughout was to assess the potential of these agents for treating battlefield injuries. Both glutamine and crocetin produced much more rapid recovery of depleted ATP levels after shock and resuscitation, decreased apoptotic mediators and apoptosis itself, and improved survival. DHEA did not improve hemodynamic response in a porcine shock model, nor did it affect ATP or apoptosis. Glutamine and crocetin are good candidates for clinical trials.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2005
Accession Number
ADA441190

Entities

People

  • Charles Van Way Iii

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Apoptosis
  • Biological Sciences
  • Blood
  • Cardiovascular Physiological Phenomena
  • Cells
  • Chemistry
  • Clinical Trials
  • Combat Casualty Care
  • Combat Injuries
  • Feeding Methods
  • Glutamine
  • Hemorrhagic Shock
  • Macrophages
  • Resuscitation
  • Standards
  • Survival

Fields of Study

  • Medicine

Readers

  • Cardiovascular Physiology
  • Prostate Cancer Biology.