NYS Center of Excellence in Bioinformatics
Abstract
This Center is made up of an integrated set of research projects in five areas. The overall mission of the center is to utilize state-of-the-art systems biology approaches to the generation of novel therapies and diagnostics for human diseases. Drug Discovery & Delivery: Biologically relevant compounds that can be linked to effects on specific gene expression patterns, creating new drug targets. Included in this program are two new start-up companies. Cancer: Identify targets to inhibit tumor growth and cell proliferation. Neurodegenerative Disease: Investigating the disease mechanisms of several neurological disorders, including Alzheimer's, MS, Krabbe's and Parkinson's disease. Major themes include demyelination, amyloid plaque formation, and loss of cellular function. Cardio-Vascular disease; Mechanisms by which inflammatory processes associated with clinical aspiration events progress to pneumonitis and ventilator-associated pneumonias; sudden cardiac failure due to arrhythmias. Pathogenesis & Biodefense: Investigation of virulence factors for bacteria and viruses important in human disease and in bio-warfare. Novel vaccines and anti-microbial agents will be developed based on structure-function understanding of these factors. Data Intensive Core; Analysis of genomic, proteomic, epidemiological and clinical data, imaging, and modeling.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 21, 2005
- Accession Number
- ADA441201
Entities
People
- Bruce Holm
Organizations
- State University of New York at Albany