A Diet, Physical Activity, and Meditation Intervention in Men With Rising Prostate-Specific Antigen (PSA)
Abstract
Following surgery or radiation of primary early-stage prostate cancer (PrCA), one in three patients will experience an elevation in serum prostate antigen (PSA) within 10 years. This rises to one in two at 15 years. After such evidence of recurrence, the most common treatment is androgen ablation. We hypothesize that the host-PrCA balance in asymptomatic men with biochemically recurrent PrCA, as reflected by the PSA rise, is favorably affected by an intensive, vegetable-based diet, plus physical activity and mindfulness-based stress reduction. This randomized trial will enroll 60 men with rising PSA levels along with a partner of his choice. Half of enrollees will be randomized to the intervention and half to usual care. The intervention will continue for 3 months, followed by monthly booster sessions for 3 months. Data will be collected on main study outcomes, protocol compliance and adherence, and potential effect modifiers, mediators, and confounders of treatment effect.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2005
- Accession Number
- ADA441261
Entities
People
- James R Hébert
Organizations
- University of South Carolina