Targeting of Breast Cancer with Triptolide Nanoparticles

Abstract

Triptolide (TPL), a diterpenoid triepoxides-like molecule purified from Tripterygium wilfordii Hook F, is a potent anti-tumor agent. However, the effect of TPL on breast cancer is not well studied. In past year, we have successfully finished the following works: 1) demonstrated the effectiveness of TPL in inhibition of breast cancer growth in vitro; 2) examined the effect of TPL in anti-growth of breast cancer xenografts; 3) synthesized and preparation of RGD/NGRPA- TPL-lipo; 4) examined the inhibitory effect of RGD/NGR-PA-TPL-lipo on growth of tumor cells in vivo in CAM model. The effect of RGD/NGR-PA-TPL-lipo on breast cancer xenografts and its angiogenesis will be further studied.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2005
Accession Number
ADA441278

Entities

People

  • Shanmin Yang

Organizations

  • University of Rochester

Tags

DTIC Thesaurus Topics

  • Angiogenesis
  • Biomedical Research
  • Blood
  • Blood Vessels
  • Breast Cancer
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Clinical Trials
  • Diseases And Disorders
  • Endothelial Cells
  • Inhibition
  • Medical Personnel
  • Molecules
  • Nanoparticles
  • Neoplasms
  • Targeting

Fields of Study

  • Chemistry

Readers

  • Allergy and Immunology.
  • Molecular Biology and Genetics

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech