Intensity Modulated Radiation Treatment of Prostate Cancer Guided by High Field MR Spectroscopic Imaging
Abstract
With the development of computer controlled multileaf collimators, IMRT now provides unprecedented means for us to deliver 3D-dose distributions with sub-centimeter resolution. Simultaneously, MRSI is capable of noninvasively providing critically needed 3D metabolic and physiological information. Together with anatomical CT/MRI, functional imaging affords valuable 4D data (3D structural plus 1D metabolic). A timely issue is how to integrate the metabolic/functional data into IMRT planning to improve clinical prostate cancer management. Toward establishing biologically conformal radiation therapy for prostate treatment, we have carried out a series of studies and developments and have successfully accomplished a number of important milestones of the proposed project. These include refined the endorectal coil-based 3T prostate MRSI technique for prostate imaging; developed a narrow band technique for deformable image registration of endorectal coil-based MRI/MRSI and treatment planning CT images; developed a novel inverse planning system that is capable of incorporating prior clinical knowledge; established an adaptive technique for producing optimal voxel-dependent penalty scheme for prostate IMRT planning; proposed a biological model-based BCRT inverse planning technique and laid technique foundation for BCRT. It is expected these tools will greatly facilitate the imaging, planning, delivery, and quality assurance of MRSI-guided prostate treatment.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2005
- Accession Number
- ADA442246
Entities
People
- Lei Xing
Organizations
- Stanford University