Genetic Epidemiology of Prostate Cancer
Abstract
Prostate cancer results from complex interactions among genetic, endocrine, and environmental factors. Understanding genetic risk factors that contribute to the occurrence of prostate cancer is crucial to design both preventative and therapeutic strategies and to identify at-risk individuals. This knowledge could reduce the incidence of and death from this disease. The primary objective of this grant is to investigate changes in genes that directly and indirectly regulate levels of male hormones, which in turn, affect prostate cell growth, and may ultimately cause cancer. In this past year, we have performed genotyping for variants in INS and IRS2 to analyze in conjunction with the IRS1 and IGF1 variant genotypes to look at main effects and gene x gene interactions. In addition, we investigated haplotypes in IGFBP1 and SHBG in order to assess the association with variation across the entire gene. Statistical methods were used to analyze the association of these genes with occurrence of prostate cancer, age at diagnosis and disease aggressiveness. The IRS1 variant was associated with a 2.7 fold increased risk of prostate cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2005
- Accession Number
- ADA442276
Entities
People
- Susan L. Neuhausen
Organizations
- University of California, Irvine