Carcinogenicity and Immunotoxicity of Embedded Depleted Uranium and Heavy-Metal Tungsten Alloy in Rodents

Abstract

This study investigates the carcinogenic and immunotoxic potential of embedded fragments of depleted uranium (DU) and a heavy-metal tungsten alloy (WA). Male Fisher 344 rats were surgically implanted with pellets of DU, WA, tantalum (inert metal, negative control), or nickel (known carcinogen, positive control). We previously reported that implanted WA resulted in the rapid formation of tumors, identified as rhabdomyosarcomas, surrounding the pellets. In Year 4 we found that these tumors had, within the same area, histopathological characteristics of both the pleomorphic and embryonal subtypes of rhabdomyosarcomas.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2005
Accession Number
ADA442322

Entities

People

  • Alexandra C. Miller
  • David E. Mcclain
  • John F. Kalinich

Organizations

  • Henry M. Jackson Foundation for the Advancement of Military Medicine

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Arteries
  • Blood
  • Blood Cells
  • Body Weight
  • Cancer
  • Cardiovascular System
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Environment
  • Laboratory Animals
  • Lymphatic System
  • Lymphocytes
  • Medical Personnel
  • Thymocytes
  • Tungsten Alloys
  • Wounds And Injuries

Readers

  • Nuclear Non-Proliferation and International Security
  • Powder metallurgy of Titanium alloys.
  • Toxicology/Environmental Toxicology