Exercise to Counteract Loss of Bone and Muscle During Androgen Deprivation Therapy in Men With Prostate Cancer

Abstract

The objective is to determine whether a 1-year intensive resistance exercise training (RT) program is more effective than a moderate-intensity walking program in ameliorating the effects on body composition of androgen deprivation therapy (ADT). It is postulated that, in men on ADT for the treatment of locally advanced prostate cancer: 1) RT will attenuate the declines in bone mineral density (BMD) and fat-free mass (FFM) to a greater extent than walking; and 2) both RT and walking will prevent an increase in fat mass. Primary outcomes are lumbar spine BMD and FFM. Secondary outcomes are: total body and hip BMD; fat mass; markers of bone turnover; serum sex hormones; physical functional performance; and quality of life. Local project support will enable assessment of risk factors for cardiovascular disease (blood lipids, glucose tolerance, arterial stiffness).

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2005
Accession Number
ADA442327

Entities

People

  • L. M. Glode
  • Robert S. Schwartz
  • Wendy M. Kohrt

Organizations

  • University of Colorado Health

Tags

DTIC Thesaurus Topics

  • Androgens
  • Body Composition
  • Bone Diseases
  • Cardiovascular Diseases
  • Databases
  • Deprivation
  • Diseases And Disorders
  • Health Services
  • Hormones
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Quality Of Life
  • Resistance
  • Risk Factors
  • Sex Hormones
  • Spine

Fields of Study

  • Medicine

Readers

  • Cardiovascular Physiology
  • Prostate Cancer Biology.
  • Trauma Surgery or Emergency Medicine.