Outcomes by Ethnicity: Sentinel Lymph Node Status in Women With Breast Cancer
Abstract
Breast cancer incidence and outcomes vary in women of different racial/ethnic backgrounds. Race/ethnicity and tumor biology may affect outcomes. Since regional lymph node status and tumor markers are strong prognostic indicators, this study examines the role of sentinel lymph node status (SLNS) and cyclin E levels in outcomes for women of various races/ethnicities with breast cancer. Data was collected for 400 women from two cohort groups using existing database and medical records. Data included tumor size, nodal status, estrogen receptor status, HER-2/neu status, cyclin E levels and race/ethnicity. A new data base organizes unique study data: socioeconomic status and health-related behaviors. Data quality checks and abstraction continue. Subjects will be matched for as many factors as possible. The final sample of 50 Whites/non-Hispanic and 50 others, including Hispanics, will be analyzed to correlate SLNS to race/ethnicity, cyclin E levels to race/ethnicity and SLNS to cyclin E levels. Disease-free survival and overall survival rates cannot be determined for several years and thus are not available during the award period. It is hypothesized prognostic accuracy of SLNS and cyclin E levels are Independent of racial/ethnic factors. This finding would suggest SLNS and cyclin E levels could discriminate outcomes within different racial/ethnic groups.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2005
- Accession Number
- ADA442358
Entities
People
- Kelly K. Hunt
- Khandan Keyomarsi
- Mary Hassett
Organizations
- The University of Texas MD Anderson Cancer Center