CYP1B1 Polymorphism as a Risk Factor for Race-Related Prostate Cancer
Abstract
The main goal of this project is to investigate whether polymorphisms of the CYP1B1 gene can be a risk factor for race-related prostate cancer. Two specific aims were proposed and are as follows: 1) To test the hypothesis that CYP1B1 gene is hyper-activated during malignant transformation of race-related prostate cells; and 2) To test the hypothesis that single nucleotide polymorphisms (SNPs) of the CYP1B1 gene have higher risk for race-related prostate cancer and correlate with hyper-activated CYP1B1 gene. We have obtained 77 benign prostatic hyperplasia (BPH) and 5% prostate cancer (PC) samples from African-American and Caucasian patients. The first hypothesis is under experimentation. To analyze whether SNPs of CYP1B1 gene are risk factors for race-related PC, two polymorphic sites at codons 119 and 432 have been evaluated. Based on the samples obtained, between races, the variant allele at codon 432 appears to be a risk factor among Blacks compared to Whites for both BPH (P<0.01) and PC (P=0.06). No difference was detected at codon 119. Within race, no differences were observed between BPB and PC at either SNP site. The continuation of SNP studies with additional samples to be collected and experimentation with aim #1 will be the focus in years 2 and 3.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2005
- Accession Number
- ADA442362
Entities
People
- Rajvir Dahiya
- Yuichiro Tanaka
Organizations
- Northern California Institute for Research and Education