Energetics and Structure Prediction of the Network of Homo- and Hetero-Oligomers Formed by the Transmembrane Domains of the ErbB Receptor Family of Proteins

Abstract

The erbB/HER receptor proteins use a single transmembrane domain to mediate growth factor induced signal transduction across membranes. A complex network of both homo- and hetero-oligomeric interactions exists for the members of this receptor family. The goals of our research are to examine the role played by the transmembrane domain in this network of interactions. We have measured the energetics of homo- and hetero-oligomerization for the four human erbB transmembrane domains. We find all interactions to be modest in energy. We have developed a thermodynamic model to distinguish random interactions of proteins in micelles from preferential ones. We propose that the erbB transmembrane domains do not require strong preferential interactions in order to enhance the interaction propensity for a covalently bound soluble domain.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2005
Accession Number
ADA442679

Entities

People

  • Karen G Fleming

Organizations

  • Johns Hopkins University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Amino Acids
  • Biochemistry
  • Cell Line
  • Cell Membrane
  • Cell Physiological Processes
  • Cells
  • Chemical Reactions
  • Chemical Synthesis
  • Chemistry
  • Crystal Structure
  • Department Of Defense
  • Growth Factors
  • Membrane Lipids
  • Molecules
  • Oligomers
  • Proteins
  • Statistical Distributions

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