Evaluation of the Role of the Metastasis-Suppressor Gene MKK4/SEK1 in Transgenic Models of Prostate Cancer

Abstract

Metastasis-suppressor genes suppress the growth of metastases without affecting tumor growth. We have been studying the role of inactivation of one such metastasis suppressor gene, Map Kinase 4 (MKK4) in the process of metastatic colonization. Work proposed in this application is aimed at extending our ongoing studies in the AT6. 1 model system into established transgenic models of prostate cancer and the use of transgenic approaches to test further MKK4's metastasis suppressor activity. In the past year we have applied the tools generated in the preceding year and found a need for changing our experimental design. As described in this report, we are establishing new collaborations to address these issues. We are also obtaining additional frozen samples to strengthen our correlative studies.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2004
Accession Number
ADA442682

Entities

People

  • Carrie W. Rinker-schaeffer

Organizations

  • University of Chicago

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Cancer
  • Cells
  • Chromosomes
  • Detection
  • Diseases And Disorders
  • Experimental Design
  • Genetics
  • Metastasis
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Suppressors
  • Teamwork
  • Test And Evaluation
  • Therapy
  • Tissues

Fields of Study

  • Biology

Readers

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  • Oncology and Biomarker-Based Cancer Detection.
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