Oral Administration of N-Acetyl-D Glucosamine Polymer Particles Down-Regulates Airway Allergic Responses
Abstract
This is an annual report of the 2nd grant year. PI and 2 Research Associates moved to the current Institute September 2003 from East Carolina University, Greenville, NC and requested transfer of grantee institute. The request was approved on December 1, 2004. The project was re-started in December 2004 with a planned end date of March 23, 2007. Since there was no funding for 14 months during the transfer process, our progress has been limited. We requested a no-cost extension until May 23, 2008, addressed to Pat McAllister, USA MED RESEARCH ACQ ACTIVITY Office, on January 6 2005. This is pending. We established that our chitin particle preparations induce cytokines that down-regulate allergic immune responses. Although other immunomodulators including bacterial endotoxin (LPS), DNA and cell walls (HK-BCG) also induce similar profiles of cytokine production, they additionally induce splenic PGE2-macrophage formation and the production of IL-10, a pro-inflammatory cytokine. Interestingly, all these agonists including chitin particles induce mitogen-activating protein kinases (MAPK) consisting of p38, JNK and Erk1/2. We found that, among agonists, cytokine production is mediated differentially by MAPK families.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2005
- Accession Number
- ADA442684
Entities
People
- Yoshimi Shibata
Organizations
- Florida Atlantic University