Detection of Metastatic Potential in Breast Cancer by RhoC-GTPase and WISP3 Proteins

Abstract

This is the third annual report for a project that aims at understanding the clinical utility of RhoC-GTPase and WISP3 proteins in breast cancer patients. These two genes were identified as key genetic determinants of inflammatory breast cancer (IBC). We believe that RhoC GTPase and WISP3 act in concert to determine a highly metastatic breast cancer phenotype, and that they may help identify which invasive breast carcinomas are aggressive from the outset and treat them more appropriately before the development of metastases. Specifically, we aim to determine whether detection of RhoC GTPase and WISP3 proteins in breast cancer tissue samples can identify aggressive tumors. A second goal of our award is to determine the effect of farnesyl transferase inhibitors (FTIs) in RhoC overexpressing xenografts. This award resulted in significant contributions to advance the knowledge of IBC and generate novel hypotheses.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2005
Accession Number
ADA442688

Entities

People

  • Celina G Kleer

Organizations

  • University of Michigan

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cells
  • Culture Media
  • Database Management Systems
  • Databases
  • Detection
  • Diseases And Disorders
  • Epithelial Cells
  • High Density
  • Inhibition
  • Neoplasms
  • Relational Databases
  • Statistical Analysis
  • Tissues

Readers

  • Child and Adolescent Substance Abuse Science in Autism Spectrum Disorders.
  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology