Targeted Killing of Breast Tumor Stem Cells

Abstract

It has been postulated that the heterogeneous, metastatic breast cancer cells are originated from a single or a small number of distinct tumor stem cells, and that only the cancer stem cells have the unlimited ability to proliferate and metastasize to different tissues and organs. A recent study found that the CD44+/CD24- breast tumor cells may be breast tumor stem cells. CD44 is a receptor that binds to hyaluronan (HA), a carbohydrate consisting of Beta1,3 N-acetyl glucosaminyl-Beta1,4 glucuronide. We have proposed to generate CD44-targeted liposome to selectively destroy the CD44+ breast tumor cells. Toward the goal, we have prepared HA molecules from human umbilical cord hyaluronic acid by hydrolysed by Bee venom. However, we have encountered the technical difficulty to produce CD44-targeted liposomes that are incorporated with HA molecules. Due to the technical problems, this proposed study has been extended for additional one year.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2004
Accession Number
ADA442800

Entities

People

  • Si-yi Chen

Organizations

  • Baylor College of Medicine

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Carbohydrates
  • Cells
  • Fetus
  • Light Scattering
  • Mammary Glands
  • Molecules
  • Neoplasms
  • Particle Size
  • Stem Cells
  • Synthetic Membranes

Readers

  • Molecular and Cellular Biochemistry
  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech