Characterization of a Novel Intracellular Receptor for Phorbol Esters and Diacylglycerol in Prostate Cancer
Abstract
The small GTP-binding protein Rac controls essential functions, including actin cytoskeleton reorganization, cell proliferation, cell cycle progression, adhesion, migration and invasion. The relationship of Rac to prostate carcinogenesis has not been extensively studied. However upstream activators of Rac have been described to be hyperactivated in prostate cancer, and it is well known that growth factors are very important in the control of prostate cancer proliferation and progression, as well as in the maintenance of growth during androgen independency. Chimaerins, through their Rac-GAP activity, accelerate the hydrolysis of GTP from Rac, leading to its inactivation. To date four chimaerin isoforms have been isolated and reported: alpha2, alpha2-, beta1- and beta2- Chimaerin. While alpha1- and beta1 -chimaerin are restricted to brain and testis, respectively, alpha2- and alpha2-chimaerin are widely expressed. No experimental information has been reported about the possible role of chimaerins in prostate cancer. Likewise, there are no information available about the expression of different chimaerin in prostate cancer cell lines. Our work hypothesis is that by inhibiting Rac function in prostate cancer cells, chimaerins will impair proliferation and reduce the invasive properties of prostate cancer cells.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2005
- Accession Number
- ADA442814
Entities
People
- Jose L. Martinez
Organizations
- University of Pennsylvania