Expression and Promoter Methylation of P16INK4A During Estrogen-Induced Mammary Carcinogenesis in the ACI Rat

Abstract

Breast cancer is one of the leading causes of death for women in the United States and estrogen exposure has been hypothesized to be involved in the development of this cancer. Our lab is studying the ACI rat, an estrogen-induced breast cancer animal model to begin to elucidate estrogen's role in breast cancer. The ACI rat develops mammary cancer after prolonged exposure to 17beta-estradiol, while the BN and genetically related COP rats do no. We have identified several polymorphisms in the promoter region of p16(sup cdkn2a) between the ACI rat and either the BN or COP rats. These polymorphisms lead to changes in expression and methylation of p16(sup cdkn2a).

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2005
Accession Number
ADA442858

Entities

People

  • Lois M. Bartsch

Organizations

  • University of Nebraska Medical Center

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Breast Cancer
  • Cell Physiological Processes
  • Continents
  • Department Of Defense
  • Electronic Mail
  • Estrogens
  • Geographic Regions
  • Governments
  • Hyperplasia
  • Information Operations
  • Methylation
  • National Governments
  • Neoplasms
  • North America

Fields of Study

  • Biology

Readers

  • Cardiovascular Physiology
  • Molecular and genetic basis of cancer.

Technology Areas

  • Biotechnology