Simultaneous Monitoring of Vascular Oxygenation and Tissue Oxygen Tension of Breast Tumors Under Hyperbaric Oxygen Exposure
Abstract
The goals of the study in the first stage are 1) to develop a mathematic model by which we can derive tumor blood flow and metabolic rate of oxygen from hemoglobin concentration during interventions, 2) to investigate vascular oxygenation and tissue oxygen tension of breast tumor under continuous normobaric and hyperbaric oxygen exposures with several gas interventions, using near-infrared spectroscopy and FOXY oxygen sensor simultaneously. The results show that the fitted tumor blood flow and metabolic rate of oxygen showed different responses between oxygen and carbogen interventions by applying our model. The simultaneous measurements by broadband diffuse spectroscopy and FOXY oxygen sensor demonstrate that hyperbaric oxygen improves both the tumor vascular and tissue oxygen level more effectively than normobaric oxygen.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2005
- Accession Number
- ADA442876
Entities
People
- Mengna Xia
Organizations
- University of Texas at Arlington