Cerebrovascular Involvement in Liposome - Induced Cardiopulmonary Distress in Pigs
Abstract
Intravenous administration of liposomes, including Doxil, can cause severe life threatening hemodynamic changes in pigs. The reaction is due to complement activation, and it is characterized by massive pulmonary hypertension, systemic hypotension and severe cardiac abnormalities including falling cardiac output, tachy- or bradycardia with arrhythmia. There were no data suggesting the involvement of cerebrovascular changes in this reaction, however clinical observations allowed this hypothesis. Here we measured the accompanying changes during liposome infusion by monitoring pulsatile electrical impedance (rheoencephalogram - REG) on the skull (n =24 pigs, 57 trials, 19 types of liposomes). A transient but significant decrease of REG pulse amplitudes followed the injection of liposomes (78.43% in the total sample, and 91.66% in the Doxil subgroup; P = 0.003, n = 12), indicating the involvement of cerebrovascular reaction during liposome infusion.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2005
- Accession Number
- ADA442978
Entities
People
- Carl R. Alving
- F. J. Pearce
- J. Baranyi
- J. Szebeni
- M. Bodo
- R. Bunger
- S. Savay
Organizations
- Walter Reed Army Institute of Research