Enhanced Peptide of Prostate Cancer Using Targeted Adenoviral Vectors
Abstract
An adenovirus encoding the genes for human somatostatin receptor subtype 2 has been constructed and evaluated in human prostate cancer cells with regard to binding of 64Cuoctreotide. In vivo experiments were conducted in scid mice bearing subcutaneous DU-145 or PC-3 cells. AdSSTR2 was injected intratumorally followed 48 h later by an i.v. injection of 64Cu-octreotide. The mice were sacrificed I h after peptide injection for biodistribution analysis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2005
- Accession Number
- ADA442988
Entities
People
- Buck E. Rogers
Organizations
- Washington University in St. Louis