Randomized, Double Blind, Placebo controlled Trial of Neuroprotective Effects of Epoetin Alfa in Patients Receiving Adjuvant Chemotherapy for Breast Cancer

Abstract

Adjuvant treatment with Adriamycin and cyclophosphamide (AC) clearly prolongs the overall survival in women with breast cancer. Cognitive deficits (e.g. problems with memory and concentration) are common during and after adjuvant breast cancer chemotherapy, but the pathophysiology of cognitive phenomena is unknown. The goal of this project is to study the pathophysiology of cognitive dysfunction in patients receiving adjuvant treatment using Positron Emission Tomography (PET) scan. This study opened to accrual in April 2003. Three patients have been enrolled.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2005
Accession Number
ADA443053

Entities

People

  • Edward Crowell
  • Gary Marano
  • Jame Abraham
  • Marc Haut
  • Sobha Kurian

Organizations

  • West Virginia University

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Blood Flow
  • Brain
  • Breast Cancer
  • Chemotherapy
  • Cognitive Impairment
  • Department Of Defense
  • Drug Therapy
  • Dysfunction
  • Neoplasms
  • Pathophysiology
  • Positron Emission Tomography
  • Positron Emissions
  • Positrons
  • Tomography
  • United States
  • West Virginia

Fields of Study

  • Medicine

Readers

  • Clinical Trial Research.
  • Medical Imaging.
  • Oncology (Cancer Research).