Proteinated Subnano Particles of Elemental Selenium for the Treatment of Breast Cancer
Abstract
The purpose of this award is to test in preclinical models the hypothesis that cytotoxic conjugates of elemental selenium and proteins are safe and effective for the systemic therapy of invasive breast cancer. The grant has three specific aims, to evaluate the safety and efficacy of systemically administered Se(O)-protein conjugates in athymic nude mice bearing xenografts of human breast cancer cells; to assess the functional integrity of conjugate treated normal human hematopoietic stem cells; and to determine by use of the combination index method how Se(O)-protein conjugates interact with standard chemotherapeutic agents that are commonly used in the treatment of invasive breast cancer. We report here on the successful custom synthesis and subsequent physical, chemical, and biological characterization of the selenomerocyanine dye MC54, the essential pro-drug for the generation of Se(0)-protein conjugates, as well as an extension of the in vitro evaluation of Se(O)-protein conjugates to additional human breast cancer cell lines.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2005
- Accession Number
- ADA443081
Entities
People
- Fritz Sieber
Organizations
- Medical College of Wisconsin