A Bioengineered Gene Therapy System with Potential to Heal War Wounds
Abstract
Wound healing is a controlled coordinated response to tissue injury leading to scar tissue formation. It involves complex interactions between cell types, matrix and soluble mediators. When one or more of these components is disrupted, wound healing is delayed or even halted. There has been some success with topical application of growth factors to improve healing in the face of sepsis and infection. However the effects have been modest. A major limitation of topical application of growth factors is that they are destroyed rapidly by tissue proteases. The gene therapy approach we propose will have the advantage of continually producing growth factors within the wound to constantly replenish tissue levels. Our approach also allows the production of multiple growth factors to maximize potential benefit.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 2005
- Accession Number
- ADA443096
Entities
People
- John W. Harmon
Organizations
- Johns Hopkins University