Molecular Effects of I3C/DIM in Prostate Cancer Cells

Abstract

Our previous data have shown that 13C inhibits cell growth and induces apoptosis in cancer cells. We have also observed a reduction in the activated Akt and the activity of NF-kappaB in prostate cancer cells treated with I3C. By gene transfection and kinase assay, we have found that the inhibition of NF-kappaB by I3C and DIM was partly mediated through the inactivation of Akt. 13C and DIM inhibited phosphorylation of Akt, inactivated NF-KB, and regulated the expression of genes related to cell growth and apoptosis.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2005
Accession Number
ADA443250

Entities

People

  • Fazlul Sarkar

Organizations

  • Wayne State University

Tags

DTIC Thesaurus Topics

  • Antineoplastic Agents
  • Biological Factors
  • Breast Cancer
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Epithelial Cells
  • Neoplasms
  • Peptide Growth Factors
  • Prostate Cancer
  • Proteins
  • Tumor Cell Line

Fields of Study

  • Biology
  • Chemistry

Readers

  • Molecular Biology and Genetics