A Viable Neuroprotection Strategy Following Soman-induced Status Epilepticus

Abstract

The present study examined the neuroprotective effectiveness of dantrolene in the prevention of soman-induced SRBD. (Dantrolene is FDA approved for the treatment of malignant hyperthermia.) The decision to consider this compound is based on its well-known mode of action in preventing the release of calcium from intracellular stores. In addition, we assessed possible synergistic overlap in the neuroprotective effectiveness of combined dantrolene and diazepam co-treatment. The combined neuroprotective effectiveness of diazepam+dantrolene is compared with that of diazepam+HU-211 (dexanabinol). The present results provide strong evidence that, by blocking the release of calcium from intracellular stores, dantrolene synergistically augmented the neuroprotection produced by diazepam alone.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2003
Accession Number
ADA443565

Entities

People

  • G. P. Ballough
  • M. G. Filbert

Organizations

  • United States Army Medical Research Institute of Chemical Defense

Tags

DTIC Thesaurus Topics

  • Anticonvulsants
  • Body Temperature
  • Brain
  • Brain Injuries
  • Cell Physiological Processes
  • Central Nervous System
  • Enzyme Inhibitors
  • Epilepsy
  • Free Radicals
  • Hyperthermia
  • Nerve Agents
  • Poisoning
  • Postoperative Complications
  • Programmed Cell Death
  • Rodents
  • Seizures
  • Thalamus

Fields of Study

  • Medicine

Readers

  • Neurotoxicology
  • Neurotrauma and Rehabilitation Medicine.
  • Oncology (Cancer Research).