A CpG Oligonucleotide Can Protect Mice From a Low Aerosol Challenge Dose of Burkholderia mallei
Abstract
Oligonucleotides containing CpG motifs were tested for protective efficacy in a mouse Burkholderia mallei aerosol challenge model. CpG 7909 protected all mice from death up to 7 weeks after challenge. The lungs from treated mice were protected from infection. Preexposure therapy may protect victims of a biological attack from glanders.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2006
- Accession Number
- ADA443582
Entities
People
- Arthur M. Krieg
- David M. Waag
- Michael J. Mccluskie
- Ningli Zhang
Organizations
- United States Army Medical Research Institute of Infectious Diseases