Monoclonal Antibodies Passively Protect BALB/c Mice Against Burkholderia mallei Aerosol Challenge

Abstract

Glanders is a debilitating disease with no vaccine available. Murine monoclonal antibodies were produced against Burkholderia mallei, the etiologic agent of glanders, and were shown to be effective in passively protecting mice against a lethal aerosol challenge. The antibodies appeared to target lipopolysaccharide. Humoral antibodies may be important for immune protection against B. mallei infection.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2006
Accession Number
ADA443590

Entities

People

  • Amy R. Permenter
  • David M. Waag
  • Marilyn J. England
  • Narayanan Parthasarathy
  • Paul H. Gibbs
  • Sylvia R. Treviño
  • Tran C. Chanh

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Animal Diseases
  • Animals
  • Antibodies
  • Antigens
  • Bacterial Structures
  • Cells
  • Chemistry
  • Diseases And Disorders
  • Immune Serums
  • Immunity
  • Infection
  • Infectious Diseases
  • Laboratory Animals
  • Lipopolysaccharides
  • Microorganisms
  • Proteins
  • Wound Infections

Fields of Study

  • Biology

Readers

  • Immunology

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech