Effects of Naturally-Occurring Estrogen-Fatty Acid Esters on Mammary Cell Growth and Carcinogenesis in Female Rats

Abstract

This is the final report for the Predoctoral Taineeship Award (No. DAMD17-02-1-0567). The studies described in the original grant proposal have been completed. The major findings included the following: (i) We demonstrated, for the first time, that the naturally-occurring estrogen fatty acid esters have a differential, strong mitogenic effect in the fat-rich mammary tissues, and this effect was not observed with estradiol. (ii) We showed that the endogenous estrogen fatty acid esters are pathogenically more important than estradio for the selective induction of mammary tumor formation. (iii) We found that the estrogen esterase activity is higher in the breast tissue than in the uterus, which provides the bases for our hypothesis, the endogenous estrogen-fatty acid esters are mammary-selective estrogens for stimulation of cell growth and cancer formation.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2005
Accession Number
ADA443677

Entities

People

  • B. T. Zhu
  • Laura H. Mills
  • Won J. Lee

Organizations

  • University of South Carolina

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Blood
  • Breast Cancer
  • Cancer
  • Cells
  • Cellular Structures
  • Esters
  • Estrogens
  • Fatty Acid Esters
  • Fatty Acids
  • Hormones
  • Inhibition
  • Mammary Glands
  • Microsomes
  • Neoplasms
  • South Carolina

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