The Role of Bone Marrow-Derived Stem Cells on Mammary Tumor Angiogenesis, Growth and Metastasis, and the Influence of VEGF-A and PIGF on Their Recruitment

Abstract

The goal of this CDA was to investigate the regulation of Endothelial precursor cells by endothelial cell specific cytokines in mammary tumors. Initial studies anticipated a critical role of VEGF and PlGF, based on their ability to promote survival signaling in endothelial cells. Our investigations also pointed to another cytokine-receptor family-the Tie-2 signaling pathway%in EPCs in breast cancer and in survival signaling through the Akt pathway (1, 2). Ongoing studies have pointed to Akt as a common downstream signaling pathway that may mediate proliferation and homing of EPCs to mammary tissue and mammary tumors. Transgenic models are proposed to regulate Akt signaling and mammary tumor promotion to investigate the I relationship between EPCs and mammary tumor angiogenesis..

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2005
Accession Number
ADA443684

Entities

People

  • Laura E. Benjamin

Organizations

  • Beth Israel Deaconess Medical Center

Tags

DTIC Thesaurus Topics

  • Angiogenesis
  • Blood
  • Blood Vessels
  • Bone Marrow
  • Breast Cancer
  • Cancer
  • Carcinoma
  • Cell Physiological Processes
  • Cells
  • Crystal Structure
  • Endothelial Cells
  • Gene Expression
  • Medical Personnel
  • Molecules
  • Neoplasms
  • Proteins
  • Stem Cells

Fields of Study

  • Medicine

Readers

  • Immunology and Pathology
  • Molecular Biology and Genetics

Technology Areas

  • Biotechnology