Testing Whether Defective Chromatin Assembly in S-Phase Contributes to Breast Cancer
Abstract
We showed that defects in chromatin assembly trigger DNA damage, a potent source of genome instability and cause of human cancers. Although we failed to make a specific link between defects in chromatin assembly and breast cancer, our survey was not exhaustive and leaves open the possibility that future studies might reveal such a link. Second, we showed that the histone chaperones HIRA and ASF 1 a drive formation of specialized domains of facultative heterochromatin in senescent cells and senescence-associated cell cycle exit. Although the funding period has ended, my lab is continuing to investigate whether genetic' alterations of HIRA and ASF 1 a and other factors in this pathway contribute to cancers of breast and other tissues.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2005
- Accession Number
- ADA443724
Entities
People
- Peter D. Adams
Organizations
- Fox Chase Cancer Center