NSAIDS and the Osteogenic Response to Mechanical Stress in Premenopausal Women
Abstract
This is a study of the effects of ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), on the osteogenic response to 9 months of exercise training in healthy, premenopausal women, aged 21 to 40 years (N=102). The hypotheses are: H1a: taking short-acting NSAIDS before exercise will diminish increases in bone mineral density (BMD) in response to exercise training H1b: taking short-acting NSAIDS after exercise will not diminish the increases in BMD in response to exercise training. Participants take either ibuprofen (4OOmg) or placebo capsules before and after each exercise session. Women are randomized to three treatment arms: NSAID before exercise, placebo after exercise (NSAID/placebo; n=34); placebo before exercise, NSAID after exercise (placebo/NSAID; n=34); and placebo before exercise, placebo after exercise (placebo/placebo; n=34). One hundred thirteen women completed baseline testing and were randomized to treatment; 62 women have completed the study. Final follow-up testing and sample analyses will be completed in the next 4-5 months. These studies could lead to the development of new strategies to reduce the incidence of, and treatment for, stress fractures that occur in response to vigorous physical activity.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2005
- Accession Number
- ADA443759
Entities
People
- Robert S. Schwartz
- Wendy M. Kohrt
Organizations
- University of Colorado Health