Efficacy of Calcium and Vitamin D Supplementation for the Prevention of Stress Fractures in Female Naval Recruits
Abstract
The goal of this project is to determine if calcium and vitamin D intervention can reduce the incidence of stress fracture by at least 50% in female Naval recruits during basic training. The secondary goal is to examine the potential mechanisms for increasing bone adaptation to intense mechanical loading. We will recruit 5200 recruits who will be randomly assigned to an intervention group given calcium 2000 mg and vitamin D 800 I.U. per day or a control placebo group. The intervention and stress fracture monitoring will continue through 8 weeks of basic training. In a subset of 560 subjects, we will obtain peripheral quantitative computed tomography(pQCT)measurements of the tibia at baseline and end of training to determine changes in moment of inertia. To date we have enrolled 4606 subjects and completed 3518. We have enrolled 113 into the pQCT substudy. We continue to enroll and collect data. To date, 249 subjects have sustained stress fractures. There have been no adverse events since the last annual report. We have requested a no-cost extension to complete the study. We have no findings to report.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2005
- Accession Number
- ADA443761
Entities
People
- Joan M. Lappe
Organizations
- Creighton University