Therapeutic Potential of a Novel Smac/DIABLO in Breast Cancer

Abstract

The objectives of this study was to examine the intracellular mechanisms by which Smac/DIABLO sensitizes TRAiL-resistant breast cancer cells to undergo apoptosis, and enhances the therapeutic potential of tamoxifen, doxorubicin and paclitaxel. Overexpression of Smac/DIABLO gene or Smac peptide enhances the apoptosis-inducing potential of tamoxifen, doxorubicin and paclitaxel, and sentitizes TRAiL-resistant breast cancer cell lines. The effects of combination treatments with Smac/DIABLO and drugs on apoptosis, growth inhibition, and caspase activation were higher than the single treatment alone. Thus, the combination of Smac/DIABLO with tamoxifen, doxorubicin, paclitaxel or TRAIL may be used as a new therapeutic approach for breast cancer therapy.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2005
Accession Number
ADA443883

Entities

People

  • Rakesh K. Srivastava

Organizations

  • University of Maryland, Baltimore

Tags

DTIC Thesaurus Topics

  • Alkenes
  • Antineoplastic Agents
  • Apoptosis
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Instructions
  • Molecules
  • Neoplasms
  • Proteins
  • Tumor Cell Line

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Oncology (Cancer Research).