Long Term Outcomes of BRCA1/BRCA2 Mutation Testing

Abstract

This project aims to gain a better understanding of the implications of genetic testing for breast-ovarian cancer susceptibility. The primary goal is to evaluate the impact of BRCA1/BRCA2 mutation testing on long term psychosocial (quality of life, distress, social functioning) and prevention/surveillance (mammography, CA125, transvaginal ultrasound, prophylactic mastectomy, prophylactic oophorectomy and chemoprevention) outcomes. To accomplish this we will measure outcomes within a group of women who received BRCA1/BRCA2 test results at least four years ago. We will divide our sample based upon their personal cancer history - evaluating cancer survivors with different measures compared to unaffected individuals. For both survivors and unaffected individuals we will recruit separate comparison samples of women who have never received BRCA1/BRCA2 testing. During this past year we received final approval from the DOD to begin accrual. We have initiated accrual and to date have completed follow-up interviews with xxx women. During the upcoming year we will continue accrual of our genetic testing cohort and will initiate accrual of our comparison groups.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2005
Accession Number
ADA443929

Entities

People

  • Marc D. Schwartz

Organizations

  • Georgetown University

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Cancer
  • Cancer Screening
  • Contracts
  • Data Analysis
  • Databases
  • Department Of Defense
  • Drug Therapy
  • Genetic Testing
  • Mammography
  • Mutations
  • Neoplasms
  • Ovarian Cancer
  • Personnel Management
  • Quality Of Life
  • Social Psychology
  • Ultrasounds

Fields of Study

  • Medicine

Readers

  • Clinical Trial Research.
  • Molecular and genetic basis of cancer.
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.

Technology Areas

  • Biotechnology