Ovarian Cancer Risk and Survival in BRCA 1/2 Carriers

Abstract

Our research efforts to date suggest that both OC use and childbearing are protective in BRCA1/2 carriers and non-carriers. Our findings also suggest that there are unknown genetic and/or environmental factors that alter the risk of ovarian cancer, especially among BRCA1/2 carriers. It is possible that genetic variations in the inflammation pathway may be one such genetic factor and that exposure to inflammation-associated factors may be one such environmental factor. This research has produced 3 abstracts, 1 journal article, 1 manuscript under review and resulted in further funding from the NCI to investigate the role of modifiers of ovarian cancer risk in BRCA1/2 carriers.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2005
Accession Number
ADA444028

Entities

People

  • Francesmary Modugno

Organizations

  • University of Pittsburgh

Tags

DTIC Thesaurus Topics

  • Breast Cancer
  • Cancer
  • Diseases And Disorders
  • Drug Therapy
  • Epidemiology
  • Families (Human)
  • Genetic Phenomena
  • Genetic Variation
  • Genetics
  • Health Services
  • Ligation
  • Medical Personnel
  • Neoplasms
  • Ovarian Cancer
  • Public Health
  • United States

Readers

  • Molecular and genetic basis of cancer.
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.

Technology Areas

  • Biotechnology