Modeling Shrimp Biomass and Viral Infection for Production of Biological Countermeasures
Abstract
We consider a novel approach for developing a stable operational platform for the rapid production of large quantities of therapeutic and/or preventative countermeasures. The ideas developed here can also serve as the foundations in designing an economical platform for the production of complex protein therapeutics to replace mammalian cell culture production methods used in the pharmaceutical industry. This approach involves recruiting the biochemical machinery in an existing biomass for the production of a vaccine or antibody by infection using a virus carrying a passenger gene for the desired countermeasure. While our motivation derives from efforts related to first response to deliberate bio toxic attacks on populations, the models we develop may also have use in designing prophylactic production systems against epidemics originating naturally in populations which, without intervention, might result in pandemics. While our model is specific to virus growth and vaccine production in shrimp, the implications for other crustaceans are obvious. And of course the shrimp models we investigate can serve as a foundation for understanding viral progression in other species important to marine agriculture.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 09, 2005
- Accession Number
- ADA444188
Entities
People
- A Dhar K.
- C. L. Browdy
- F. C. Allmutt
- H. Thomas Banks
- R. A. Bullis
- S. Hu
- V. A. Bokil
Organizations
- North Carolina State University