A Dynamic Model for Induced Reactivation of Latent Virus
Abstract
Many viral pathogens establish latency and are dormant. The presence of inducers leads these pathogens to reactivate and replicate, aiding their transmission and contributing to disease development. In addition, there is increasing evidence in the literature for the importance of polymicrobial infections in which microorganisms interact in a synergistic fashion, impacting both pathogenesis and maintenance of health. Among these, virus-bacteria interactions have been described, including reactivation of latent virus by metabolic end products of anaerobic bacteria. A shift in the balance of the flora often controlled by the intact immune system may reflect significant morbidity particularly in the immune suppressed host. The relationships between viral pathogens and their inducing agents have not previously been described mathematically. Therefore, to begin to understand the relationship between pathogens and their inducing agents particularly in a polymicrobial environment, we have developed a mathematical mode that describes the reactivation of latent herpes virus by metabolic end products of anaerobic bacteria.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 04, 2005
- Accession Number
- ADA444241
Entities
People
- G. M. Kepler
- H. K. Nguyen
- H. Thomas Banks
- J. Webster-cyriaque
Organizations
- North Carolina State University