The Role of HER-2 in Breast Cancer Bone Metastasis
Abstract
The major goal of this Concept award is to define the role for the growth factor receptor, HER2, in breast cancer growth in the bone and its involvement in bone metastasis. To achieve this, the authors proposed three tasks: (1) analysis of an orthotropic model of breast cancer growth in the bone, (2) immunohistochemical analysis of bone resorption and bone resorption markers, and (3) identification of potential HER2 targets involved in bone resorption. The results show that overexpression of HER2 could enhance breast cancer bone metastases. In their pilot study, the authors found that when injected into the tibia of nude mice, breast cancer cells that overexpress HER2 induced osteolytic lesions that were more aggressive than that of the parental cell line expressing low levels of HER2. Thus, HER2 may contribute to an increase in osteolytic activity of breast cancer bone metastases and further experiments may show that HER2 may serve as a therapeutic target for controlling breast cancer bone metastases. During the 1-year funding period of this grant, the authors experienced setbacks in their model system that hindered the completion of tasks outlined in this award. They have remedied these obstacles and are actively pursuing the proposed experiments. Therefore, they would like to ask for a 1-year nonfunded extension of this grant to facilitate the completion of the outlined tasks.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2005
- Accession Number
- ADA444250
Entities
People
- Dihua Yu
Organizations
- The University of Texas MD Anderson Cancer Center